ATOMIC WEIGHTS

Solubility
Only where a special, quantitative solubility test is given in the individual monograph, and is designated by a test heading, is it a test for purity.
The approximate solubilities of Pharmacopeial and National Formulary substances are indicated by the descriptive terms in the accompanying table. The term “miscible” as used in this Pharmacopeia pertains to a substance that yields a homogeneous mixture when mixed in any proportion with the designated solvent.

Descriptive Term Parts of Solvent Required
for 1 Part of Solute

Very soluble                                                Less than 1
Freely soluble                                                 From 1 to 10
Soluble                                                            From 10 to 30
Sparingly soluble                                              From 30 to 100
Very slightly soluble                                     From 1000 to 10,000

Practically insoluble, or Insoluble 10,000 and over
Soluble Pharmacopeial and National Formulary articles, when brought into solution, may show traces of physical impurities, such as minute fragments of filter paper, fibers, and other particulate matter, unless limited or excluded by definite tests or other specifications in the individual monographs.

SOLUBILITIES

Approximate Solubilities of USP and NF Articles

	Name and Volume, in mL, of Solvent
Solute (1 g)	Water	Boiling Water	Alcohol	Chloroform	Ether	Other
Acenocoumarol	67,000		280	130	1800
Acetaminophen		20	10			1 N sodium hydroxide, 15
Acetohexamide			230	210
Acetylcysteine	5		4
Acetyldigitoxin	6100		62.5	12	>10,000
Ammonium Alum	7	0.5
Aluminum Chloride	0.9		4
Aluminum Sulfate	1
Amantadine Hydrochloride	2.5		5.1	18		polyethylene glycol 400, 70
Amaranth	15
Aminocaproic Acid	3					methanol, 450
Aminohippuric Acid	45		50			3 N hydrochloric acid, 5
Aminosalicylate Sodium	2
Ammonium Carbonate	4
Amodiaquine Hydrochloride	25		78	>10,000	>10,000	benzene, 10,000
Anethole1			2
Anileridine	>10,000		2	1
Anileridine Hydrochloride	5		80	>10,000	>10,000
Antimony Potassium Tartrate	12	3				glycerin, 15
Apomorphine Hydrochlo- ride	50		50			water at 80, 20
Apraclonidine Hydrochloride	34		74	>10,000		methanol, 13; ethyl ac- etate, >10,000; hexanes, >10,000
Ascorbic Acid	3		40
Ascorbyl Palmitate	>1000		125	>1000	>1000
Aspirin	300		5	17	10 to 15
Atropine	460		2	1	25	water at 80, 90
Atropine Sulfate	0.5	2.5	5			glycerin, 2.5
Bendroflumethiazide			23		200
Benoxinate Hydrochloride	0.8		2.6	2.5	>10,000
Benzalkonium Chloride (anhydrous)					100	benzene, 6
Gamma Benzene Hexachloride				3.5	40	dehydrated alcohol, 20
Benzethonium Chloride	<1		<1	<1	6000
Benzocaine	2500		5	2	4	almond oil or olive oil, 30–50
Benzoic Acid	300		3	5	3
Benzonatate	<1		<1	<1	<1
Betadex	54
Betamethasone	5300		65	325		warm alcohol, 15; meth- anol, 3
Betamethasone Acetate	2000		9	16
Betamethasone Sodium Phosphate	2		470	>10,000	>10,000
Betamethasone Valerate	10,000		16	<10	400
Bisacodyl	>10,000		210	2.5	275
Boric Acid	18	4	18			boiling alcohol, 6; glycerin, 4
Bromodiphenhydramine Hydrochloride	<1		2	2	3500	isopropyl alcohol, 31
Brompheniramine Maleate	5		15	15
Busulfan						acetone, 45
Butabarbital Sodium	2		7	7000	10,000
Butamben	7000
Butylated Hydroxyanisole			4.0	2.0	1.2
Butylated Hydroxytoluene			4.0	1.1	1.1
Caffeine (hydrous)	50		75	6	600
Calcium Chloride	0.7	0.2	4			boiling alcohol, 2
Calcium Gluconate	30	5
	(slowly)
Calcium Hydroxide	630	1300
Calcium Lactate	20
Calcium Pantothenate	3
Calcium Sulfate	375	485
Camphor	800		1	0.5	1
Carbinoxamine Maleate	<1		1.5	1.5	8300
Carisoprodol	2083		2.5	2.3		acetone, 2.5
Cephaloridine	5		1000	10,000	10,000
Cetylpyridinium Chloride	4.5		2.5	4.5
Chloral Betaine	1		4	>10,000	>10,000	0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1
Chloral Hydrate	0.25		1.3	2	1.5
Chlorambucil						acetone, 2
Chloramphenicol	400
Chlordiazepoxide	>10,000		50	6250	130
Chlorobutanol	125		1			glycerin, 10
Chlorocresol	260		0.4
Chloroprocaine Hydro- chloride	20		100
Chlorpheniramine Maleate	4		10	10
Chlorpromazine			3	2	3	benzene, 2
Chlorpromazine Hydro- chloride	1		1.5	1.5
Chlortetracycline Hydro- chloride	75		560
Cholesterol			100			dehydrated alcohol, 50
			(slowly)
Citric Acid	0.5		2		30
Clindamycin Palmitate Hydrochloride			3			ethyl acetate, 9
Clindamycin Phosphate	2.5		>1000	>1000	>1000
Clioquinol	>100,000		3500	120	4500
Cocaine	600		7	1	3.5	olive oil, 12; liquid petrolatum, 80–100
Cocaine Hydrochloride	0.5		3.5	15
Codeine	120		2	0.5	50
Codeine Phosphate	2.5		325			boiling alcohol, 125; water at 80, 0.5
Codeine Sulfate	30		1300			water at 80, 6.5
Colchicine	25				220
Cortisone Acetate			350	4		acetone, 75; dioxane, 30
Cupric Sulfate	3	0.5	500			glycerin, 3
Cyanocobalamin	80
Cyclizine Hydrochloride	115		115	75
Cyproheptadine Hydro- chloride	275		35	26		methanol, 1.5
Dehydrocholic Acid			100	35	2200 (15)	acetic acid at 15, 135; acetone at 15, 130; benzene at 15, 960; ethyl acetate at 15, 135
Demeclocycline			200			methanol, 40
Demeclocycline Hydro- chloride	60					methanol, 50
Denatonium Benzoate	20		2.4	2.9	5000
Desipramine Hydro- chloride	12		14	3.5	>10,000
Dexamethasone Sodium Phosphate	2
Dexbrompheniramine Maleate	1.2		2.5	2	3000
Dexchlorpheniramine Maleate	1.1		2	1.7	2500
Dextroamphetamine Sulfate	10		800
Dextromethorphan Hydrobromide	65
Dextrose	1		100
Diazepam	333		16	2	39
Dibucaine	4600		0.7	0.5	1.4
Dicyclomine Hydrochlo- ride	13		5	2	770	glacial acetic acid, 2
Diethylpropion Hydro- chloride	0.5		3	3
Digitoxin			150	40
Dihydroergotamine Mesylate	125		90	175	2600
Dimercaprol	20
Dimethisterone			3	0.7
Diphenhydramine Hydro- chloride	1		2	2		acetone, 50
Disulfiram	>5000		30		15
Docusate Calcium	3300		>1	>1	>1
Docusate Sodium	70 (slowly)
Doxapram Hydrochloride	50
Doxylamine Succinate	1		2	2	370
Droperidol	10,000		140	4	500
Dyclonine Hydrochloride	60		24	2.3	>10,000	hexane, >10,000
Dydrogesterone	>10,000		40	2	200
Echothiophate Iodide	1					dehydrated alcohol, 25; methanol, 3
Edrophonium Chloride	0.5		5
Enalaprilat	200		>1000			dimethylformamide, 40; methanol, 68
Ephedrine	20		0.2
Ephedrine Hydrochloride	3		14
Ephedrine Sulfate	1.3		90
Epinephrine Bitartrate	3
Ergotamine Tartrate	500		500
Erythromycin	1000
Erythromycin Estolate			20	10		acetone, 15
Estradiol			28	435	150
Estradiol Cypionate	>10,000		40	7	2800
Estrone			250 (15)	110 (15)		boiling alcohol, 50; boiling chloroform, 80; acetone at 50, 50; boiling acetone, 33; boiling benzene, 145
Estropipate	>2000		>2000	>2000	>2000	warm alcohol, 500
Ethacrynic Acid			1.6	6	3.5
Ether1	12
Ethyl Vanillin	100		2
	(50)
Ferrous Gluconate	5
Ferrous Sulfate	1.5	0.5
Flumethasone Pivalate	>10,000		89	350	2800
Fluocinolone Acetonide	>1000		45	25	350
Fluorometholone	>10,000		200	2200	>10,000
Fluphenazine Enanthate			<1	<1	2
Fluphenazine Hydro- chloride	1.4		6.7
Flurandrenolide			72	10		methanol, 25
Flurazepam Hydrochloride	2		4	90	5000	methanol, 3; isopropa- nol, 69; benzene, 2500; petroleum ether, 5000
Fluroxene	220
Fructose			15			methanol, 14
Gentian Violet			10			glycerin, 15
Glyceryl Monostearate				10.0	100.0	methanol, 100; isopro- pyl alcohol, 33
Glycine	4		1254			water at 50, 2.6; at 75, 1.9; at 100, 1.5
Glycopyrrolate	4.2		30	260	35,000
Guaifenesin	60–70
Halazone	>1000		140	>1000	>2000
Haloperidol	>10,000		60	15	200
Heparin Sodium	20
Histamine Phosphate	4
Homatropine Hydro- bromide	6		40	420
Hydralazine Hydrochloride	25		500
Hydrocortisone			40			acetone, 80
Hydrocortisone Acetate			230	200
Hydrocortisone Sodium Phosphate	1.5
Hydroflumethiazide	>5000		39	>5000	2500
Hydromorphone Hydro- chloride	3
Hydroquinone	17		4	51	16.5
Hydroxocobalamin	50		100	10,000	10,000
Hydroxyzine Hydro- chloride	1		4.5	13	>1000
Hydroxyzine Pamoate	>1000		700	>1000	>1000	dimethylformamide, 10; 10 N sodium hydroxide, 3.5
Hyoscyamine Hydrobro- mide			2.5	1.7	2300
Hyoscyamine Sulfate	0.5		5
Ichthammol	10
Indigotindisulfonate Sodium	100
Indomethacin			50	30	40
Iodine	3000		13			carbon disulfide, 4; glycerin, 80
Ipodate Sodium	<1		2			dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsul- foxide, 3.5
Isoniazid	8		50
Isopropamide Iodide	50		10	5
Isopropyl Alcohol	<1		<1	<1	<1
Isoproterenol Hydrochlo- ride	3		50
Isoproterenol Sulfate	4		>2000	>2000	>2000
Isoxsuprine Hydrochloride	500		100	>10,000	>10,000	0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100
Ketamine Hydrochloride	4		14	60	>10,000	methanol, 6; absolute alcohol, 60
Lactose	5	2.6
	(slowly)
Levorphanol Tartrate	50		120
Levothyroxine Sodium	700		300
Lisinopril	10		>10,000	>10,000	>10,000	methanol, 70
Magnesium Hydroxide	>10,000		>10,000	>10,000	>10,000
Magnesium Sulfate	0.8	0.5				glycerin, 1 (slowly)
Mannitol	5.5
Menadione			60			benzene, 10; vegetable oils, 50
Mesoridazine Besylate	1		11	3	6300
Methacholine Chloride	1.2		1.7	2.1
Methacrylic Acid Copolymer						water in methanol (3 in 100), 10; water in alcohol (3 in 100), 10; water in isopropyl alcohol (3 in 100), 10; water in acetone (3 in 100), 10
Methacycline Hydro- chloride	100		300	>1000	>1000	0.1 N sodium hydrox- ide, 25
Methdilazine Hydro- chloride	2		2	6	>10,000	0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1
Methenamine	1.5		12.5	10	320
Methenamine Mandelate			10	20	350
Methimazole	5		5	4.5	125
Methocarbamol	40
	(20)
Methotrimeprazine	10		10	2		methanol, 10
Methoxyflurane	500		<1	<1	<1
Methsuximide	350		3	<1	2
Methyclothiazide	>10,000		92.5	>10,000	2700
Methylbenzethonium Chloride	0.8		0.9	>10,000	0.7
Methylene Blue	25		65
Methylergonovine Maleate	100		175	1900	8400
Methylparaben	400		3		10	water at 80, 50
Methylprednisolone	10,000		100	800	800
Methylprednisolone Acetate	1500		400	250	1500
Methylprednisolone Sodium Succinate	1.5		12	>10,000	>10,000
Methysergide Maleate	200		165	3400	>10,000
Miconazole	>100,000		9.5	2	15	isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3
Miconazole Nitrate	6250		312	525	50,000	isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75
Morphine Sulfate	16		570			alcohol at 60, 240; water at 80, 1
Nalidixic Acid	>1000		910	29	>1000
Neomycin Sulfate	1
Niacin	60
Niacinamide	1.5	10	5.5
Nifedipine	>10,000					acetone, 10
Nitrofurazone	4200		590			propylene glycol, 350
Nitromersol	>2000		>2000	>2000	>2000
Norepinephrine Bitartrate	2.5		300
Norethindrone Acetate	>10,000		10	<1	18	dioxane, 2
Nortriptyline Hydro- chloride	90		30	20		methanol, 10
Oxandrolone	5200		57	<5	860	acetone, 69
Oxazepam	>10,000		220	270	2200
Oxtriphylline	1
Oxymetazoline Hydro- chloride	6.7		3.6	862
Oxymetholone	>10,000		40	5	82	dioxane, 14
Oxymorphone Hydrochlo- ride	4		100	>1000	>1000	methanol, 25
Oxytetracycline	4150			>10,000	6250	absolute alcohol, 66
Oxytetracycline Calcium	>1000		>1000	>1000	>1000	0.1 N sodium hydro- xide, 15
Papaverine Hydrochloride	30		120
Paraldehyde1	10	17
Paramethasone Acetate				50		methanol, 40
Paromomycin Sulfate	<1		>10,000	>10,000	>10,000
Pectin	20
Penicillin G Benzathine	5000		65
Sterile Penicillin G Procaine	250		30	60
Sterile Penicillin G Sodium	40
Penicillin V Benzathine	3200		330	42	910	acetone, 37
Penicillin V Potassium			150
Pentazocine	>1000		11	2	42
Pentazocine Hydrochloride	30		20	4	>10,000
Pentobarbital	>2000		4.5	4.0	10
Pentolinium Tartrate	0.5		475	>1000	>2000
Perphenazine			7			acetone, 13
Phenazopyridine Hydro- chloride	<10	20	59	331	>5000	cold water, 300; glycerin, 100
Phenindamine Tartrate	40		350
Phenmetrazine Hydro- chloride	0.4		2	2
Phenobarbital	1000		10
Phenol	15					mineral oil, 70
Phentolamine Mesylate	1		4	700
Phenylethyl Alcohol	60		<1	<1	<1	alcohol solution (1 in 2), 2; diethyl phthalate, <1; benzyl benzoate, <1
Phenylmercuric Acetate	180		225	6.8	200
Phenylmercuric Nitrate	600
Phenylpropanolamine Hydrochloride	1.1		7.4	4100
Physostigmine Salicylate	75		16	6	250
Physostigmine Sulfate	4		0.4		1200
Pilocarpine Hydrochloride	0.3		3	360
Pilocarpine Nitrate	4		75
Piminodine Esylate	>1000		6	2	>1000
Pimozide	>10,000		1000	10	1000	acetone, 100; methanol, 1000; 0.1 N hydro- chloride acid, >1000
Polyethylene Glycol 1540	1			3		absolute alcohol, 100
Polyethylene Glycol 4000	4		2.5	2
Potash, Sulfurated	2
Potassium Acetate	0.5	0.2	3
Potassium Alum	7	0.3
Potassium Benzoate	2		75			alcohol solution (9 in 10), 50
Potassium Chloride	2.8	2
Potassium Citrate	1					glycerin, 2.5
Potassium Gluconate	3
Potassium Hydroxide	1		3			glycerin, 2.5
Potassium Iodide	0.7	0.5	22			glycerin, 2
Potassium Permanganate	15	3.5
Potassium Sodium Tartrate	1
Potassium Sorbate	4.5		35	>1000	>1000
Pramoxine Hydrochloride				35
Prednisolone			30	180		acetone, 50
Prednisolone Acetate			120
Prednisolone Hemisucci- nate	4170		6.3	1064	248
Prednisolone Sodium Phosphate	4					methanol, 13
Prednisone			150	200
Prilocaine Hydrochloride	3.5		4.2	175
Primaquine Phosphate	15
Primidone	2000		200
Procaine Hydrochloride	1		15
Prochlorperazine Edisylate	2		1500
Prochlorperazine Maleate			1200
Procyclidine Hydro- chloride	35		9	6	11,000
Promazine Hydrochloride	3
Propoxycaine Hydro- chloride	2		10	>10,000	80
Propoxyphene Napsylate	10,000		15	10
Propylhexedrine	>500		0.4	0.2	0.1
Propylparaben	2500	400	1.5		3
Protriptyline Hydro- chloride	2		3.5	2.5	>10,000
Pseudoephedrine Hydro- chloride	0.5		3.6	91	7000
Pyrazinamide	67			135	1000	absolute alcohol, 175; methanol, 72
Pyridoxine Hydrochloride	5		115
Pyrilamine Maleate	0.5		3	2		absolute alcohol, 15
Pyrimethamine			200	125
Pyrrocaine Hydrochloride	1.5		12	8
Quinidine Sulfate	100		10	15
Quinine Sulfate	500		120
Reserpine			1800	6
Resorcinol	1		1
Rotoxamine Tartrate	10		100	>10,000	>10,000
Saccharin	290	25	31
Saccharin Calcium	2.6		4.7
Saccharin Sodium	1.5		50
Salicylic Acid	460	15	3	45	3	benzene, 135
Scopolamine Hydro- bromide	1.5		20
Secobarbital						0.5 N sodium hydro- xide, 8.5
Selenium Sulfide				161	1667
Sennosides	35		2100	3700	6100
Silver Nitrate	0.4	0.1	30			boiling alcohol, 6.5
Simethicone2	>10,000			102	102	benzene, 102; absolute alcohol, >10,000
Sodium Acetate	0.8	0.6	19
Sodium Ascorbate	1.3
Sodium Benzoate	2		75			90 percent alcohol, 50
Sodium Bicarbonate	12
Sodium Bisulfite	4
Sodium Borate	16	1				glycerin, 1
Sodium Carbonate	3	1.8
Sodium Chloride	2.8	2.7				glycerin, 10
Sodium Citrate (hydrous)	1.5	0.6
Sodium Fluoride	25
Sodium Formaldehyde Sulfoxy- late	3.4		510	175	180
Sodium Hydroxide	1
Sodium Iodide	0.6		2			glycerin, 1
Sodium Lauryl Sulfate	10
Sodium Nitrite	1.5
Sodium Phosphate, Dried	8
Sodium Propionate	1	0.65	24	>10,000	>10,000
Sodium Thiosulfate	0.5
Sorbic Acid	1000		10	15	30	absolute alcohol, 8; methanol, 8; propylene glycol, 19
Sorbitol	0.45
Stanozolol	>1000		41	74	370
Stearic Acid			20	2	3
Stibophen	1		>10,000	>10,000	10,000
Succinylcholine Chloride	1		350
Sucrose	0.5	0.2	170
Sucrose Octaacetate	1100		11			acetone, 0.3; benzene, 0.6; toluene, 0.5
Sulconazole Nitrate	3333		100	333		pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000
Sulfacetamide Sodium	2.5
Sulfadiazine	13,000					human serum at 37, 620
Sulfadiazine Sodium	2
Sulfadimethoxine			200			2 N hydrochloric acid, 50
Sulfaethidole	>3000		75	1300	1700	methanol, 51; acetone, 13; benzene, 2277
Sulfamethizole	2000		38	1900	1900	acetone, 13
Sulfamethoxazole	3400		50	1000	1000	carbon disulfide, 2 (slowly and usually incompletely)
Sulfapyridine	3500		440			acetone, 65
Sulfasalazine	>10,000		2900	>10,000	>10,000	methanol, 1500
Sulfisoxazole	7700					boiling alcohol, 10
Sulfisoxazole Acetyl			176	35	1064	methanol, 203
Precipitated Sulfur						carbon disulfide, 2 (slowly and usually incompletely) olive oil, 100
Tartaric Acid	0.8	0.5	3		250	methanol, 1.7
Terpin Hydrate	200	35	13	140	140	boiling alcohol, 3
Testolactone	4050
Testosterone				2	100	absolute alcohol, 6
Tetracaine	>1000		5	2	2
Tetracycline	2500		50
Tetracycline Hydrochloride	10		100
Tetrahydrozoline Hydro- chloride	3.5		7.5	>1000	>1000
Theophylline Sodium Gly- cinate	6
Thiamine Hydrochloride	1		170
Thiamine Mononitrate	44
Thiethylperazine Maleate	1700		530	>10,000	>10,000
Thimerosal	1		12
Thioguanine			7700
Thiotepa	13		8.3	1.9	4.1
Thiothixene	>10,000			2	120	absolute alcohol, 110
Thiothixene Hydrochloride	8			280	>10,000	absolute alcohol, 270
Thymol	1000		1	1	1.5	olive oil, 2
Tolazoline Hydrochloride	<1		2	3	>10,000
Triamcinolone Diacetate			13	80		methanol, 40
Triamterene						formic acid, 30; 2- methoxyethanol, 85
Triazolam	>10,000		1000	25	>10,000	0.1 N hydrochloric acid, 600
Trichlormethiazide	1100		48	5000	1400	dioxane, 9.1; dimethyl- formamide, 4.35
Trichloroethylene	>10,000
Triethylenemelamine	2.5		13	3.6		methanol, 8; acetone, 9.5; benzene, 18
Trifluoperazine Hydrochloride	3.5		11	100
Triflupromazine Hydrochlo- ride	<1		<1	1.7
Trimeprazine Tartrate	2		20	5	1800
Trimethobenzamide Hydrochloride	2		59	67	720
Trioxsalen			1150	84		methylenedichloride, 43; 4-methyl- 2-pentanone, 100
Tripelennamine Hydro- chloride	1		6	6		acetone, 350
Triprolidine Hydrochloride	2.1		1.8	1	2000
Tromethamine	1.8		45.5	>10,000
Tubocurarine Chloride	20		45
Urea	1.5		10			boiling alcohol, 1
Vanillin	100					glycerin, 20; water at 80, 20
Xylometazoline Hydro- chloride	35
Zinc Acetate	2.5		30
Zinc Chloride	0.5		1.5			glycerin, 2
Zinc Sulfate	0.6					glycerin, 2.5
1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents.